COX-2-IN-20

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COX-2-IN-20

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CAS NO:

2529451-43-0

COX-2-IN-20 (Compound 5d) 是一种选择性的、具有口服活性的COX-2抑制剂，IC₅₀为 17.9 nM。COX-2-IN-20 具有抗炎活性。

生物活性

COX-2-IN-20 (Compound 5d) is a selective and orally activeCOX-2inhibitor with anIC₅₀of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity^[1].

IC₅₀& Target

COX-2

17.9 nM (IC₅₀)

COX-1

19.3 μM (IC₅₀)

体外研究
(In Vitro)

COX-2-IN-20 (Compound 5d) shows potential anti-inflammatory activity on NO inhibition in LPS-induced RAW 264.7 cell with an IC₅₀of 2.87 μM^[1].

体内研究
(In Vivo)

COX-2-IN-20 (Compound 5d) (5 mg/kg) exhibits better in vivo anti-inflammation and gastric protection than 10 mg/kg Indomethacin^[1].

分子量

269.66

Formula

C₁₁H₉ClFN₃O₂

CAS 号

2529451-43-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.