Glucocorticoid receptor-IN-2

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2664932-65-2

Glucocorticoid receptor-IN-2 (Compound WX019) 是一种选择性的糖皮质激素受体 (glucocorticoid receptor (GR)) 调节剂，具有抗炎效果。Glucocorticoid receptor-IN-2 表现出良好的转录抑制活性，对hMMP1的IC₅₀值为 0.171 nM，也表现出一定的转录激活活性，对MMTV的EC₅₀为 0.94 nM。

生物活性	Glucocorticoid receptor-IN-2 (Compound WX019) is a selectiveglucocorticoid receptor(GR)modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with anIC₅₀of 0.171 nM againsthMMP1, and comparable transcriptional activation activity with anEC₅₀of 0.94 nM againstMMTV^[1].
体外研究 (In Vitro)	Glucocorticoid receptor-IN-2 (Compound WX019) inhibits human peripheral blood mononuclear cells TNF-α with an IC₅₀of 0.98 nM^[1]. Glucocorticoid receptor-IN-2 shows inhibitory effect on CYP3A4 with an IC₅₀of 9.12 μM^[1].
分子量	512.46
Formula	C₂₅H₂₀F₄N₆O₂
CAS 号	2664932-65-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.