Glucocorticoid receptor-IN-1

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CAS NO:

2662908-25-8

Glucocorticoid receptor-IN-1 (Compound WX002) 是一种选择性的糖皮质激素受体 (glucocorticoid receptor (GR)) 调节剂，具有抗炎效果。Glucocorticoid receptor-IN-1 表现出良好的转录抑制活性，对hMMP1的IC₅₀值为 2.11 nM，也表现出转录激活活性，对MMTV的EC₅₀为 5.59 nM。

生物活性	Glucocorticoid receptor-IN-1 (Compound WX002) is a selectiveglucocorticoid receptor(GR)modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with anIC₅₀of 2.11 nM againsthMMP1, and transcriptional activation activity with anEC₅₀of 5.59 nM againstMMTV^[1].
体外研究 (In Vitro)	Glucocorticoid receptor-IN-1 (Compound WX002) shows inhibitory effect on CYP3A4 with an IC₅₀of 16.7 μM^[1].
分子量	513.45
Formula	C₂₄H₁₉F₄N₇O₂
CAS 号	2662908-25-8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.