S-HP210 是一种有效且具有选择性的糖皮质激素受体 (GR)调节剂，对 NF-κB 转录抑制的IC50为 1.92 μM。S-HP210 抑制 LPS 诱导的多种促炎基因的转录，如IL-1β、IL-6和COX-2。S-HP210 在有效剂量下对小鼠成纤维细胞 3T3 无毒。
| 生物活性 | S-HP210 is a potent and selectiveglucocorticoid receptor(GR)with anIC50value of 1.92 μM forNF-κBtransrepression (TR). S-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β,IL-6andCOX-2. S-HP210 is nontoxic at effective doses against mouse fibroblasts 3T3 cells[1]. |
| IC50& Target | IC50: 1.92 μM (NF-κB TR)[1] |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
