ST-1006 Maleate

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ST-1006 Maleate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1196994-12-3

ST-1006 maleate 是一种有效的组胺 H4 受体 (histamine H4 receptor) 激动剂，其pK_i值为 7.94。ST-1006 maleate 具有抗炎作用。

生物活性

ST-1006 maleate is a potenthistamine H4 receptoragonist with apK_ivalue of 7.94. ST-1006 maleate has anti-inflammatory effect^[1]^[2].

体外研究
(In Vitro)

ST-1006 (10 μM) maleate is a potent inducer of basophil migration and induces migration of basophils^[2].
ST-1006 (0-100 μM) maleate suppress FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils^[2].

体内研究
(In Vivo)

ST-1006 (1-100 mg/kg; s.c.; Male CD-1 mice) maleate has anti-inflammatory effect and displays an antipruritic effect^[1].

Animal Model:	Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)^[1]
Dosage:	1-100 mg/kg
Administration:	Subcutaneous injection
Result:	Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.

分子量

599.42

Formula

C₂₄H₂₈Cl₂N₆O₈

CAS 号

1196994-12-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.