BetahistineEPImpurity C (NSC19005) is an impurity of Betahistine^[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)^[2][3].

Betahistine (0-10 μM) inhibits [¹²⁵I]iodoproxyfan binding to membranes of CHO (rH₃₍₄₄₅₎R) and CHO (hH₃₍₄₄₅₎R) cells withIC₅₀values of 1.9 μM and 3.3 μM, respectively. Lead to K_ivalues of 1.4 μM and 2.5 μM, respectively^[3].

241.33

C₁₅H₁₉N₃

5452-87-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.