Doxepin

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Doxepin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1668-19-5

Doxepin 是作为三环类抗抑郁药，可抑制血清素和去甲肾上腺素的再摄取。Doxepin 对特应性皮炎、慢性荨麻疹有治疗作用，能改善认知过程，保护中枢神经系统。Doxepin 也被认为是抗氧化应激的保护因子。

生物活性

Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclicantidepressant. Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system. Doxepin has also been proposed as a protective factor against oxidative stress^[1]^[2]^[3].

体外研究
(In Vitro)

The protective effect of doxepin is associated with the enhancement of PSD-95 and synapsin 1 expression via PI3K/AKT/mTOR signaling pathway^[4].

Western Blot Analysis^[4]

Cell Line:	SH-SY5Y human neuroblastoma cell line
Concentration:	10 ng/mL
Incubation Time:	2 h
Result:	Improved the protein expre-ssion levels of PSD-95, synapsin 1 and p-AKT in SH-SY5Y cells, and decreased the protein expression level of p-mTOR in SH-SY5Y cells.

体内研究
(In Vivo)

Doxepin (intraperitoneal injection of 1 mg/kg and 5 mg/kg doxepin once a day for 21 days) can protect against the Aβ1-42-induced memory impairment in rats^[4].

Animal Model:	SD male rats^[4]
Dosage:	1, 5mg/kg
Administration:	Doxepin (intraperitoneal injection of 1 mg/kg and 5 mg/kg doxepin once a day for 21 days)
Result:	Improved the protein expression levels of PSD-95 and synapsin 1 in hippocampus and tem-poral lobe, and decreased the protein expression level of p-AKT in hippocampus and temporal lobe after treatment of 1 mg/kg of doxepin.

Clinical Trial

分子量

279.38

Formula

C₁₉H₂₁NO

CAS 号

1668-19-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.