Cetirizine

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Cetirizine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

83881-51-0

西替利嗪

Cetirizine 是羟嗪的羧化代谢物，是第二代抗组胺药。Cetirizine 是一种特异的、口服有效的、H1 受体的长效拮抗剂。Cetirizine 标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化。

生物活性

Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamineH1-receptorantagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response^[1]^[2]^[3].

体外研究
(In Vitro)

Cetirizine (>5 μM) at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1β. Cetirizine exerts anti-inflammatory effects beyond histamine H1-receptor antagonist^{[2]^.}

Cell Viability Assay^[2]

Cell Line:	Human airway epithelial cell line A549.
Concentration:	0-10 μM.
Incubation Time:	24 h.
Result:	The survival of A549 cells incubated with various concentrations of cetirizine (0.1, 1, 2.5, 5, and 10 μM) for 24 hours were all higher than 90% when comparing with the control group by MTT test. Cetirizine, 5 and 10 μM, suppressed GM-CSF release by 70.71 and 61.55%, respectively. Preincubation with cetirizine, 10 μM, suppressed the IL-8 secretion by 75.04%.

体内研究
(In Vivo)

Cetirizine (20 mg/kg, mice, orally) exerts its anti-inflammatory effects by inhibiting MIF as well as IL-8 production in mice immunized and challenged with ragweed pollen^{[3]^.}

Animal Model:	Male 8-week-old BALB/c mice (25-30 g) immunized and challenged with ragweed pollen^{[3]^.}
Dosage:	2 or 20 mg/kg.
Administration:	Orally, diluted in sterile water on days 18, 19, and 20.
Result:	The neutrophilia at 8 h and eosinophilia at 24 h induced by ragweed pollen extract per os were significantly reduced in the mice treated with 20 mg/kg. The dosage with 2 mg/kg had no effect.

Clinical Trial

分子量

388.89

Formula

C₂₁H₂₅ClN₂O₃

CAS 号

83881-51-0

中文名称

西替利嗪；西替利嗪

结构分类

Ketones, Aldehydes, Acids

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vivo:

1.
Cetirizine is dissolved in PBS^[6].