Levocetirizine

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Levocetirizine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

130018-77-8

左西替利嗪
(R)-Cetirizine

Levocetirizine ((R)-Cetirizine) 是第三代peripheral H1-receptor拮抗剂。Levocetirizine 是一种抗组胺剂，是 Cetirizine 的 R 对映体。Levocetirizine 对组胺 H1-受体的亲和力高于 (S)-Cetirizine，并且可用于研究变应性鼻炎和慢性特发性荨麻疹。

生物活性

Levocetirizine ((R)-Cetirizine) is a third-generationperipheral H1-receptorantagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for thehistamine H1-receptorthan (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria^[1].

体内研究
(In Vivo)

Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the C_max, AUC_0-t, AUC_0-∞and t_1/2are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats^[1].

Animal Model:	30 male Sprague-Dawley rats (8 weeks old; 200-250 g)^[1]
Dosage:	0.4 mg/kg
Administration:	Oral administration (Pharmacokinetic Analysis)
Result:	The C_max, AUC_0-t, AUC_0-∞and t_1/2were 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively.

Clinical Trial

分子量

388.89

Formula

C₂₁H₂₅ClN₂O₃

CAS 号

130018-77-8

中文名称

左西替利嗪

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.