2',3'-cGAMP

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2',3'-cGAMP

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1441190-66-4

2'-3'-cyclic GMP-AMP

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) 是一种哺乳动物细胞中的内源性 cGAMP。2',3'-cGAMP 以高亲和力结合STING，是干扰素-β (IFNβ) 的有效诱导物。2',3'-cGAMP 是在哺乳动物细胞中为响应细胞质中的 DNA 而产生。

生物活性

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds toSTINGwith a high affinity and is a potent inducer ofinterferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm^[1].

IC₅₀& Target

Human Endogenous Metabolite

体外研究
(In Vitro)

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP^[1].

分子量

674.41

Formula

C₂₀H₂₄N₁₀O₁₃P₂

CAS 号

1441190-66-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vitro:

H₂O : 5 mg/mL(7.41 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.4828 mL	7.4139 mL	14.8278 mL
5 mM	0.2966 mL	1.4828 mL	2.9656 mL
10 mM	---	---	---