Isoprocurcumenol 是一种愈创木醚型倍半萜烯，可从Curcuma comosa中分离得到。Isoprocurcumenol 可以激活EGFR信号。Isoprocurcumenol 增加ERK和AKT的磷酸化。Isoprocurcumenol 可促进角质形成细胞的增殖。
| 生物活性 | Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated fromCurcuma comosa. Isoprocurcumenol can activateEGFRsignaling. Isoprocurcumenol increases the phosphorylation ofERKandAKT. Isoprocurcumenol promotes the proliferation of keratinocytes[1][2][3]. |
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体外研究
(In Vitro) | Isoprocurcumenol (10 μM, 0-1 h) 可促进 ERK 和 AKT 的磷酸化[3]。
Isoprocurcumenol (0-200 μM, 24 or 48 h) 诱导角质形成细胞 HaCaT 细胞增殖[3]。
Isoprocurcumenol (1 μM, 1 h) 通过激活 EGFR 信号通路增加细胞生长和增殖相关基因的表达，例如 c-fos、c-jun、c-myc 和 egr-1[ 3]。
Isoprocurcumenol 诱导细胞恢复和伤口愈合[3]。
Western Blot Analysis[3] | Cell Line: | HaCaT cells (human keratinocyte cell) | | Concentration: | 10 μM | | Incubation Time: | 10, 30, or 60 min | | Result: | Induced the phosphorylation of ERK and AKT after 10 min and this was sustained for 1 h. |
Cell Proliferation Assay[3] | Cell Line: | HaCaT cells (human keratinocyte cell) | | Concentration: | 0 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 25 μM, 50 μM, 100 μM, or 200 μM | | Incubation Time: | 24 or 48 h | | Result: | Showed a significant increase in the proliferation of cells at most of the Isoprocurcumenol concentrations, starting at 10 nM. |
RT-PCR[3] | Cell Line: | HaCaT cells (human keratinocyte cell) | | Concentration: | 1 μM | | Incubation Time: | 1 h | | Result: | Increased the expression of genes related to cell growth and proliferation, such as c-myc, c-jun, c-fos, and egr-1. |
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| 来源 | - Plants
- Zingiberaceae
- Curcuma comosaRoxb.
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
