Mutated EGFR-IN-1

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Mutated EGFR-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1421372-66-8

Osimertinib analog

Mutated EGFR-IN-1 (Osimertinib analog) 是突变型EGFR(L858R EGFR，Exonl9缺失活化突变和T790M抗性突变) 抑制剂的中间体。

生物活性

Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutatedEGFR, such as L858REGFR, Exonl9 deletion activating mutant and T790M resistance mutant. IC50 value: Target: MutatedEGFRinhibitor More information can be found in Patent WO 2013014448 A1.2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives asegfrmodulators useful for treatingcancer.

IC₅₀& Target^[1]

EGFR^L858R

EGFR^{Exon 19 deletion/T790M}

EGFR^T790M

分子量

445.56

性状

Solid

Formula

C₂₅H₃₁N₇O

CAS 号

1421372-66-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 75 mg/mL(168.33 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.2444 mL	11.2218 mL	22.4437 mL
5 mM	0.4489 mL	2.2444 mL	4.4887 mL
10 mM	0.2244 mL	1.1222 mL	2.2444 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。