MS9449

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MS9449

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

MS9449 是一种有效的PROTAC EGFR降解剂，对野生型 EGFR 和突变型 EGFR L858R 的K_d分别为 17 nM 和 10 nM。MS9449 通过泛素/蛋白酶体系统 (UPS) 和自噬/溶酶体途径有效诱导突变型 EGFRs 降解。MS9449 对 NSCLC 细胞增殖有较强的抑制作用。MS9449 可用于抗癌研究。

生物活性

MS9449 is a potentPROTACEGFRdegrader withK_ds of 17 nM and 10 nM forEGFRWT andEGFRL858R, respectively. MS9449 effectively induces degradation of mutant EGFRs through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9449 potently inhibits the proliferation of NSCLC cells. MS9449 can be used for researching anticancer^[1].

IC₅₀& Target^[1]

EGFR (WT)

17 nM (Kd)

EGFR L858R

10 nM (Kd)

分子量

1151.82

Formula

C₆₀H₇₆ClFN₁₀O₈S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.