EMI1

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EMI1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

35773-42-3

EMI1 是EGFR三重突变体EGFR ex19del/T790M/C797S和EGFR L858R/T790M/C797S的有效抑制剂。EMI1 可用于与 EGFR 突变相关的耐药型非小细胞肺癌 (NSCLC) 的研究。

生物活性

EMI1 is anEGFRex19del/T790M/C797SandEGFRL858R/T790M/C797Sinhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lungcancer(NSCLC)^[1].

IC₅₀& Target^[1]

EGFR^{del19 T790M C797S}

EGFR^{L858R/T790M/C797S}

体外研究
(In Vitro)

EMI1 inhibits PC9 EGFR ex19del/T790M/C797S organoid growth with the EC₅₀of 131 nM^[1].
EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1^[1].
EMI1 (1 nM-100μM) strongly inhibits the viability and increase the caspase 3/7 activity of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells^[1].

Cell Viability Assay^[1]

Cell Line:	PC9 EGFR ex19del/T790M/C797S and HBE bronchial epithelial lung EGFR-WT control cells.
Concentration:	0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time:	72 hours
Result:	Strongly inhibited the viability.

分子量

334.37

Formula

C₂₀H₁₈N₂O₃

CAS 号

35773-42-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.