EGFR-IN-51

立即咨询

EGFR-IN-51

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2418549-32-1

EGFR-IN-51 (Compound 6) 是一种有效的EGFR抑制剂，对EGFR 、EGFR L858R-TK和EGFR T790M-TK的IC₅₀值分别为 0.493、102.60 和 461.63 μM。EGFR-IN-51 对癌细胞具有毒性，诱导细胞凋亡 (apoptosis)。

生物活性

EGFR-IN-51 (Compound 6) is a potentEGFRinhibitor withIC₅₀values of 0.493, 102.60 and 461.63 μM againstEGFR,EGFRL858R-TKandEGFRT790M-TK, respectively. EGFR-IN-51 shows cytotoxic activity againstcancercell lines and inducesapoptosis^[1].

IC₅₀& Target

EGFR

0.493 μM (IC₅₀)

EGFR^L858R

102.60 μM (IC₅₀)

EGFR^T790M

461.63 μM (IC₅₀)

分子量

373.43

Formula

C₂₁H₁₅N₃O₂S

CAS 号

2418549-32-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.