EGFR-IN-21

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EGFR-IN-21

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2648206-31-7

EGFR-IN-21 是一种有效的EGFR抑制剂，IC₅₀为 0.38 nM。EGFR-IN-21 具有抗肿瘤活性。

生物活性

EGFR-IN-21 is a potentEGFRinhibtior with anIC₅₀of 0.38 nM. EGFR-IN-21 has antitumor activity^[1].

IC₅₀& Target^[1]

EGFR

0.38 nM (IC₅₀)

体外研究
(In Vitro)

EGFR-IN-21 inhibits HEK293T cells (IC₅₀=951.51 nM) and PC9 EGFR-Del19/T790M/C797S cells (IC₅₀=135.11 nM)^[1].

体内研究
(In Vivo)

EGFR-IN-21 (1 mg/kg; IV) has a T_1/2of 3.33 hours, and a V_ssof 0.374 L/kg for female CD-1 mouse^[1].
EGFR-IN-21 (5 mg/kg;po) has a T_1/2of 3.13 hours, a C_maxof 2077 ng/ml and an AUC of 7542 h·ng/ml^[1].

分子量

759.68

Formula

C₃₆H₄₄BrN₁₀O₂P

CAS 号

2648206-31-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.