EGFR-IN-56

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EGFR-IN-56

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2477726-83-1

EGFR-IN-56 (Compound 13a) 是一种有效的EGFR抑制剂，对EGFR^T790M和EGFR^T790M/L858R的IC₅₀值分别为 541.7 nM 和 132.1 nM。EGFR-IN-56 在 G2/M 期阻滞癌细胞，诱导细胞凋亡 (apoptosis)。

生物活性

EGFR-IN-56 (Compound 13a) is a potentEGFRinhibitor withIC₅₀values of 541.7 nM and 132.1 nM againstEGFR^T790MandEGFR^T790M/L858R, respectively. EGFR-IN-56 blockscancercells in G2/M phase and induce into lateapoptosis^[1].

IC₅₀& Target

EGFR^T790M

541.7 nM (IC₅₀)

EGFR^L858R/T790M

132.1 nM (IC₅₀)

分子量

434.51

Formula

C₂₃H₂₂N₄O₃S

CAS 号

2477726-83-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.