EGFR-IN-30

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EGFR-IN-30

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2726463-68-7

EGFR-IN-30 是一种有效的EGFR抑制剂，对 EGFR (WT)、EGFR (L858R/T790M/C797S) 的IC₅₀分别为 1-10 nM、<1 nM。EGFR-IN-30 具有用于细胞增殖类疾病，类如肿瘤等研究的潜力。

生物活性

EGFR-IN-30 is a potentEGFRinhibitor withIC₅₀s of 1-10 nM,<1 nm forEGFR(WT),EGFR(L858R/T790M/C797S), respectively. EGFR-IN-30 has potential for cell proliferative diseases, such ascancerresearch^[1].

IC₅₀& Target^[1]

EGFR (WT)

1-10 nM (IC₅₀)

EGFR (L858R/T790M/C797S)

<1 nM (IC₅₀)

体外研究
(In Vitro)

EGFR-IN-30 (compound 27) inhibits A431 cell (IC₅₀=100-1000 nM),Ba/F3_L858R/T790M/C797S cell (IC₅₀<10 nm), baf3_del19t790mc797s cell (ic₅₀<10 nm)^[1].

分子量

610.49

Formula

C₂₈H₃₃BrN₇O₂P

CAS 号

2726463-68-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.