EGFR-IN-36

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EGFR-IN-36

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CAS NO:

2711105-54-1

EGFR-IN-36 是一种有效的EGFR抑制剂，对 EGFR (WT)、HER2 (WT)、HER2 (A775_G776insYVMA) 的IC₅₀分别为 19.09 nM、120.01 nM、2.35 nM。EGFR-IN-36 具有用于野生和/或突变EGFR和/或HER2激酶介导的肿瘤研究的潜力。

生物活性

EGFR-IN-36 is a potentEGFRinhibitor withIC₅₀s of 19.09 nM, 120.01 nM, 2.35 nM forEGFR(WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutantEGFRand/or HER2 kinase mediated tumors research^[1].

IC₅₀& Target^[1]

EGFR (WT)

19.09 nM (IC₅₀)

HER2(WT)

120.01 nM (IC₅₀)

HER2 (A775_G776insYVMA)

2.35 nM (IC₅₀)

体外研究
(In Vitro)

EGFR-IN-36 (compound 8) inhibits A431 cell (IC₅₀=223.6 nM),A549 cell (IC₅₀=7644.42 nM), H1975 cell (IC₅₀=20.68 nM)^[1].

分子量

488.97

Formula

C₂₆H₂₅ClN₆O₂

CAS 号

2711105-54-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.