Scutellarin

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Scutellarin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

27740-01-8

野黄芩苷

Scutellarin 是从黄芩中分离到的黄酮类物质，在 HCC 细胞中，能够下调STAT3/Girdin/Akt信号通路，在破骨细胞中，能够抑制 RANKL 介导的MAPK/NF-κB信号通路。Scutellarin 具有抗HIV-1IIIB，HIV-1(74V)和HIV-1KM018的活性，EC₅₀分别为 26 μM，253 μM 和 136 μM。

生物活性

Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates theSTAT3/Girdin/Aktsignaling in HCC cells, and inhibits RANKL-mediatedMAPK andNF-κBsignaling pathway in osteoclasts. Scutellarin is active againstHIV-1IIIB,HIV-1(74V)andHIV-1KM018withEC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

IC₅₀& Target^[1]

STAT3

HIV-1

体外研究
(In Vitro)

Scutellarin treatment significantly reduces HepG2 cell viability in a dose-dependent manner, and inhibits migration and invasion of HCC cells in vitro. Scutellarin treatment significantly reduces STAT3 and Girders of actin filaments (Girdin) expression, STAT3 and Akt phosphorylation in HCC cells. Introduction of STAT3 overexpression restores the scutellarin-downregulated Girdin expression, Akt activation, migration and invasion of HCC cells. Furthermore, induction of Girdin overexpression completely abrogates the inhibition of scutellarin on the Akt phosphorylation, migration and invasion of HCC cells. Scutellarin can inhibit HCC cell metastasis in vivo, and migration and invasion in vitro by down-regulating the STAT3/Girdin/Akt signaling^[1]. Scutellarin selectively enhances Akt phosphorylation^[2]. Scutellarin is a putative therapeutic agent as it has been found to not only suppress microglial activation thus ameliorating neuroinflammation, but also enhance astrocytic reaction. Acutellarin amplifies the astrocytic reaction by upregulating the expression of neurotrophic factors among others thus indicating its neuroprotective role. Remarkably, the effects of scutellarin on reactive astrocytes are mediated by activated microglia supporting a functional "cross-talk" between the two glial types^[3]. Scutellarin can suppress RANKL-mediated osteoclastogenesis, the function of osteoclast bone resorption, and the expression levels of osteoclast-specific genes (tartrate-resistant acid phosphatase (TRAP), cathepsin K, c-Fos, NFATc1). Further investigation indicates that Scutellarin can inhibit RANKL-mediated MAPK and NF-κB signaling pathway, including JNK1/2, p38, ERK1/2, and IκBα phosphorylation^[5].

体内研究
(In Vivo)

Scutellarin (50 mg/kg/day) significantly mitigates the lung and intrahepatic metastasis of HCC tumors in vivo. The numbers of the lung and intrahepatic metastatic tumors in the scutellarin-treated group are significantly less than that in the controls^[1]. The rats treated with Scutellarin display a significant alleviation in neurobehavioral deficits compared to the SAH group. Scutellarin enhanced eNOS expression compared with SAH rats^[4].

分子量

462.36

性状

Solid

Formula

C₂₁H₁₈O₁₂

CAS 号

27740-01-8

中文名称

野黄芩苷；野黄芩甙；灯盏花乙素；高黄芩苷；高黄芩甙；印黄芩苷；黃芹素

结构分类

Flavonoids
Flavones

Phenols
Polyphenols

来源

Plants
Compositae
Blainvillea acmella(L.) Phillipson

Plants
Labiatae

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(216.28 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.1628 mL	10.8141 mL	21.6282 mL
5 mM	0.4326 mL	2.1628 mL	4.3256 mL
10 mM	0.2163 mL	1.0814 mL	2.1628 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： 0.5%CMC-Na/saline water
Solubility: 10 mg/mL (21.63 mM); Suspended solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。