STAT3-IN-12

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STAT3-IN-12

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

STAT3-IN-12 是一种有效的STAT3信号抑制剂，可以抑制 IL-6 诱导的 JAK/STAT3 信号通路的激活。STAT3-IN-12 可抑制癌细胞生长、迁移，并诱导细胞凋亡 (apoptosis) 以及周期阻滞。STAT3-IN-12 可用于癌症相关研究，如肝细胞癌 (HCC) 和食管癌。

生物活性

STAT3-IN-12 is a potentSTAT3signal inhibitor that can inhibitIL-6induced JAK/STAT3 signalling pathway activation. STAT3-IN-12 inhibitscancercell growth, migration, and induce cellapoptosisas well as cycle arrest. STAT3-IN-12 can be used in cancer-related research, such as hepatocellular carcinoma (HCC) and oesophageal carcinoma^[1].

IC₅₀& Target^[1]

STAT3

体外研究
(In Vitro)

STAT3-IN-12 (compound 24, 0-10 μM approximately, 72 h) inhibits cancer cell growth and migration in HepG2 and EC109 cells^[1].
STAT3-IN-12 (0-20 μM, 16 h) binds to the STAT3 protein and inhibits IL-6-mediated STAT3 phosphorylation, also inhibts STAT3 nuclear localization and dimerization in EC109 and HepG2 cells^[1].
STAT3-IN-12 (0-20 μM, 48 h) induces cell apoptosis as well as cycle arrest in HepG2 and EC109 cells^[1].

Cell Viability Assay^[1]

Cell Line:	HepG2 and EC109 cells
Concentration:	0, 1.25, 2.5, 5 and 10 μM.
Incubation Time:	72 h
Result:	Inhibited cancer cell growth with IC₅₀values of 4.32 and 3.63 μM.

Cell Migration Assay^[1]

Cell Line:	HepG2 and EC109 cells
Concentration:	0-10 μM
Incubation Time:	24 h
Result:	Inhibited cancer cell migration.

Western Blot Analysis^[1]

Cell Line:	HepG2 and EC109 cells
Concentration:	0, 2.5, 5, 10 and 20 μM
Incubation Time:	16 h
Result:	Inhibited phosphorylation of STAT3 tyrosine 705 with high selectivity.

体内研究
(In Vivo)

STAT3-IN-12 (compound 24, intraperitoneal injection, 20, 40 mg/kg, daily for 24 days) displays obvious antitumor activity in a mouse HepG2 cell xenograft tumor model without no obvious toxicity^[1].

Animal Model:	HepG2 cell xenograft tumor model^[1]
Dosage:	20, 40 mg/kg, daily for 24 days
Administration:	Intraperitoneal injection
Result:	Inhibited tumor growth without affecting the body weight.

分子量

454.56

Formula

C₂₈H₃₀N₄O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.