ERK5-IN-3

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ERK5-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1888305-85-8

ERK5-IN-3 (compound 33j) 是一种有效且选择性的ERK5(细胞外信号相关激酶 5) 抑制剂，其IC₅₀为 6 nM。ERK5-IN-3 对 Hela 细胞具有抗增殖活性，其IC₅₀为 31 nM。

生物活性

ERK5-IN-3 (compound 33j) is a potent and selectiveERK5(extracellular signal-related kinase 5) inhibitor, with anIC₅₀of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with anIC₅₀of 31 nM^[1].

IC₅₀& Target

ERK5

6 ± 1 nM (IC₅₀)

体内研究
(In Vivo)

ERK5-IN-3 (compound 33j) (10 mg/kg, i.v. and p.o, once) has low clearance (CL=20 mL/min/kg) and low oral bioavailability (F%=9%), with terminal elimination half-lives of 263 min^[1].

分子量

489.37

Formula

C₂₄H₂₃Cl₂FN₄O₂

CAS 号

1888305-85-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.