ACA-28 (compound 2a) 是一种有效的ERK MAPK信号调节剂。ACA-28 通过 ERK 过度激活诱导凋亡,选择性抑制癌细胞生长。ACA-28 抑制黑色素瘤细胞 (SK-MEL-28) 和正常黑色素细胞 (NHEM) 生长,IC50值分别为 5.3 和 10.1 μM。
生物活性 | ACA-28 (compound 2a) is a potentERKMAPKsignaling modulator. ACA-28 selectively inhibitscancercell growth by inducingapoptosiswithERKhyperactivation
ACA-28 inhibits cell growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), withIC50values of 5.3 and 10.1 μM, respectively[1]. |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |