ASK1-IN-3

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ASK1-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2426705-19-1

ASK1-IN-3 是一种有效且具有选择性的ASK1激酶抑制剂，IC₅₀为 33.8 nM，同时也抑制多种细胞周期调节激酶。ASK1-IN-3 具有较强的 HepG2 癌细胞凋亡 (apoptosis) 诱导活性与有效的细胞周期阻滞活性。

生物活性

ASK1-IN-3 is a potent and selectiveASK1kinase inhibitor withIC₅₀of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2cancercellsapoptosisinduction and potent cell cycle arrest activities^[1].

IC₅₀& Target

IC₅₀: 33.8 nM (ASK1)^[1]

体外研究
(In Vitro)

ASK1-IN-3 (compound 14l) (10, 20 and 50 μM; 48 hours) induces PARP cleavage in a dose dependent manner, which indicates the induction of HepG2 cells apoptosis^[1].
ASK1-IN-3 (1-16 μM; 24 hours) significantly arrests cycle progression at G1 phase^[1].

Apoptosis Analysis

Cell Line:	HepG2^[1]
Concentration:	10, 20 and 50 μM
Incubation Time:	48 hours
Result:	Induced PARP cleavage in a dose dependent manner.

Cell Cycle Analysis

Cell Line:	HepG2^[1]
Concentration:	1, 2, 4, 8, and 16 μM
Incubation Time:	24 hours
Result:	Significantly arrested cycle progression at G1 phase.

分子量

378.39

Formula

C₁₈H₁₈N₈O₂

CAS 号

2426705-19-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.