MEK/PI3K-IN-1

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MEK/PI3K-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2281803-28-7

MEK/PI3K-IN-1 (compound 6r) 是一种有效的MEK/PI3K抑制剂，其IC₅₀值分别为 124 nM (MEK1), 130 nM (PI3Kα), 和 236 nM (PI3Kδ)。MEK/PI3K-IN-1 抑制 pAKT 和 pERK1/2 水平。MEK/PI3K-IN-1 对肿瘤细胞具有抗增殖活性。

生物活性

MEK/PI3K-IN-1 (compound 6r) is a potentMEK/PI3Kinhibitor, withIC₅₀values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines^[1].

IC₅₀& Target

MEK1

124 ± 11 nM (IC₅₀)

PI3Kα

130 ± 13 nM (IC₅₀)

PI3Kδ

236 ± 29 nM (IC₅₀)

PI3Kβ

1537 ± 188 nM (IC₅₀)

PI3Kγ

2745 ± 485 nM (IC₅₀)

分子量

913.63

Formula

C₃₆H₃₇F₅IN₉O₆

CAS 号

2281803-28-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.