p38 MAP Kinase Inhibitor IV

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CAS NO:

1638-41-1

p38 MAP Kinase Inhibitor IV 是一种高度特异的 ATP 竞争性p38α MAPK抑制剂，p38 MAP Kinase Inhibitor IV 对 p38α 和 p38β MAPK 的IC₅₀分别为 0.13 和 0.55 μM。

生物活性

p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitivep38αMAPKinhibitor withIC₅₀s of 0.13 and 0.55 μM forp38αandp38βMAPK, respectively^[1].

IC₅₀& Target

p38α

0.13 μM (IC₅₀)

p38β

0.55 μM (IC₅₀)

p38δ

8.63 μM (IC₅₀)

p38χ

5.47 μM (IC₅₀)

体外研究
(In Vitro)

p38 MAP Kinase Inhibitor IV (MT4) shows IC₅₀values of 0.13, 0.55, 5.47, and 8.63μM for p38α, β, χ, andδ, respectively. p38 MAP Kinase Inhibitor IV has the suppressive action on the release of TNF-alpha and IL-1beta in PBMC with IC50 values of 22 and 44 nM, respectively^[1].

分子量

456.94

Formula

C₁₂H₄Cl₆O₄S

CAS 号

1638-41-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.