B-Raf IN 10 (Compound C09) 是一种BRAF抑制剂，IC50在 50-100 nM。B-Raf IN 10 具有抗肿瘤活性。
| 生物活性 | B-Raf IN 10 (Compound C09) is aBRAFinhibitor with anIC50between 50 and 100 nM. B-Raf IN 10 shows antitumor activity[1]. |
| IC50& Target[1] | BRAF-V600E < 50 nM (IC50) | Braf 50-100 nM (IC50) |
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体外研究
(In Vitro) | B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E[1].
B-Raf IN 10 shows an IC50between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E[1].
B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells[1].
Cell Viability Assay[1] | Cell Line: | A375, SK-MEL-28, SK-MEL-31 and CHL-1 | | Concentration: | | | Incubation Time: | 72 h | | Result: | Showed inhibition with IC50s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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| 溶解性数据 | In Vitro: DMSO : 100 mg/mL(202.23 mM;ultrasonic and warming and heat to 60℃) 配制储备液 | 1 mM | 2.0223 mL | 10.1114 mL | 20.2229 mL | | 5 mM | 0.4045 mL | 2.0223 mL | 4.0446 mL | | 10 mM | 0.2022 mL | 1.0111 mL | 2.0223 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
