RAF-IN-1 是一种有效的b/cRAF抑制剂，对 cRAF、bRAFwt，bRAFV600E的IC50分别为 3.8 nM、36 nM、29.4 nM。RAF-IN-1 对携带 bRAFV600E突变的 A375 和H358 细胞系显示细胞生长抑制作用，GI50分别为 3.4 和 2.9 nM。
| 生物活性 | RAF-IN-1 is a potentb/cRAFinhibitor with anIC50s of 3.8 nM, 36 nM, 29.4 nM for cRAF,bRAFwt, andbRAFV600E. RAF-IN-1 shows cell growth inhibition with GI50s of 3.4 and 2.9 nM for H358 and A375 cell line bearingbRAFV600Emutation, respectively[1]. |
| IC50& Target[1] | BRafV600E 29.4 nM (IC50) | BRAFWT 36 nM (IC50) | c-Raf 3.8 nM (IC50) |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
