VEGFR-2/BRAF-IN-1

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VEGFR-2/BRAF-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

VEGFR-2/BRAF-IN-1 (Compound 4b) 是一种VEGFR-2和BRAF双重抑制剂，对 VEGFR-2、BRAF^V600E和BRAF^WT的IC₅₀分别为 0.049、0.063 和 0.005 μM。VEGFR-2/BRAF-IN-1 诱导细胞凋亡，在 G1/S 期阻滞细胞周期。

生物活性

VEGFR-2/BRAF-IN-1 (Compound 4b) is a dualVEGFR-2andBRAFkinases inhibitor withIC₅₀values of 0.049, 0.063 and 0.005 μM against VEGFR-2,BRAF^V600EandBRAF^WT, respectively. VEGFR-2/BRAF-IN-1 inducesapoptosisand arrests the cell cycle mainly in the G1/S phase^[1].

IC₅₀& Target

VEGFR2

0.049 μM (IC₅₀)

BRaf^V600E

0.063 μM (IC₅₀)

BRAF^WT

0.005 μM (IC₅₀)

分子量

642.50

Formula

C₂₆H₂₀Cl₂F₃N₅O₃S₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.