VEGFR-2/BRAF-IN-2

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VEGFR-2/BRAF-IN-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

VEGFR-2/BRAF-IN-2 (Compound 4a) 是一种VEGFR-2和BRAF双重抑制剂，对 VEGFR-2、BRAF^V600E、BRAF^WT的IC₅₀分别为 0.111、0.089 和 0.071 μM。VEGFR-2/BRAF-IN-2 诱导细胞凋亡，在 G1 期阻滞细胞周期。

生物活性

VEGFR-2/BRAF-IN-2 (Compound 4a) is a dualVEGFR-2andBRAFkinases inhibitor withIC₅₀values of 0.111, 0.089 and 0.071 μM against VEGFR-2,BRAF^V600EandBRAF^WT, respectively. VEGFR-2/BRAF-IN-2 inducesapoptosisand arrests the cell cycle mainly in the G1 phase^[1].

IC₅₀& Target

VEGFR2

0.111 μM (IC₅₀)

BRaf^V600E

0.089 μM (IC₅₀)

BRAF^WT

0.071 μM (IC₅₀)

分子量

608.05

Formula

C₂₆H₂₁ClF₃N₅O₃S₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.