SHR902275

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SHR902275

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2695506-82-0

SHR902275 是一种有效、选择性和口服活性RAF抑制剂，靶向 RAS 突变癌症。对于 cRAF、bRAF^wt和 bRAF^V600E，SHR902275 对 cRAF, bRAF^wt, bRAF^V600E的IC₅₀分别为 1.6 nM、10 nM、5.7 nM。 SHR902275 显示细胞生长抑制作用，对 H358、A375、Calu6 和 SK-MEL2 细胞的 GI₅₀分别为 1.5 和 0.17 nM、0.4 nM 和 0.32 nM .

生物活性

SHR902275 is a potent, selective, and orally activeRAFinhibitor targetingRASmutant cancers. SHR902275 hasIC₅₀s of 1.6 nM, 10 nM, and 5.7 nM for cRAF,bRAF^wt, andbRAF^V600E, respectively. SHR902275 shows cell growth inhibition with GI₅₀s of 1.5 and 0.17 nM, 0.4 nM and 0.32 nM for H358, A375, Calu6, and SK-MEL2 cells respectively^[1].

IC₅₀& Target^[1]

c-Raf

1.6 nM (IC₅₀)

BRaf^V600E

5.7 nM (IC₅₀)

BRAF^WT

10 nM (IC₅₀)

分子量

512.48

Formula

C₂₆H₂₃F₃N₄O₄

CAS 号

2695506-82-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.