Cyclic ADP-ribose ammonium

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:	500 μg
市场价:	7200元

cADPR ammonium

Cyclic ADP-ribose ammonium (cADPR ammonium) 是一种有效的钙动员 (calcium mobilization) 第二信使，是通过 ADP-核糖基环化酶从 NAD⁺合成的。Cyclic ADP-ribose ammonium 主要通过Ryanodine受体介导的内质网释放以及通过TRPM2通道开放引起的细胞外流入来增加胞质钙。

生物活性	Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger forcalcium mobilizationthat is synthesized from NAD⁺by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly byRyanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening ofTRPM2 channels^[1]^[2]^[3].
IC₅₀& Target	Calcium mobilization^[1] TRPM2 channels^[3] Endogenous metabolite^[1]
体外研究 (In Vitro)	cADPR (20 nM) elicits a large rapid Ca²⁺release in sea urchin eggs homogenates^[1]. cADPR (100 μM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes^[4]. cADPR (100 μM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture^[5].
体内研究 (In Vivo)	cADPR (100 μM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice^[5].
性状	Solid
Formula	C₁₅H₂₁N₅O₁₃P₂.xNH₃
结构分类	Others
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)