SAK3

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SAK3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1256269-87-0

SAK3 是一种有效的 T 型电压门控Ca²⁺通道 (T-VGCC) 增强剂。SAK3 增强 Cav3.1 和 Cav3.3 T 型 Ca²⁺通道电流。急性 SAK3 给药可改善嗅球切除小鼠的记忆缺陷。SAK3 通过激活蛋白酶体活性抑制 APP-KI 小鼠中淀粉样蛋白 β 斑块形成。

生物活性

SAK3 is a potent T-type voltage-gatedCa²⁺channels(T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca²⁺channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice^[1]. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating theproteasomeactivity^[2].

体外研究
(In Vitro)

SAK3 (0.01-10 nM) significantly enhances Cav3.1 or Cav3.3 currents in neuro2A cells ectopically expressing Cav3.1 or Cav3.3, respectively^[1].

Cell Viability Assay^[2]

Cell Line:	Cav3.1 or Cav3.3-overexpressing neuro2A cells
Concentration:	0.1 nM
Incubation Time:	270 s
Result:	Rapidly increased Ca²⁺currents

体内研究
(In Vivo)

Acute SAK3 (0.5 mg/kg) oral administration promotes acetylcholine (ACh) release in hippocampal CA1 via T-VGCC stimulation via enhancing T-type Ca²⁺channel^[1].

Animal Model:	Animal Model:Cav3.1 knockout (KO) mice^[1]
Dosage:	0.5 mg/kg
Administration:	Administered p.o.
Result:	Significantly increased ACh release in CA1, peaking at 20 min after oral administration.

分子量

369.41

性状

Solid

Formula

C₂₀H₂₃N₃O₄

CAS 号

1256269-87-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month