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NSC 207895(XI-006)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
NSC 207895(XI-006)图片
CAS NO:58131-57-0
包装与价格：
包装价格(元)
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NSC 207895 (XI-006) (XI-006) 是一种 DNA 损伤剂，是一种抗癌剂和 p53 激活剂。
Cas No.58131-57-0
别名4-(4-甲基-1-哌嗪基)-7-硝基-2,1,3-苯并二唑3-氧化物,XI-006
化学名4-(4-methylpiperazin-1-yl)-7-nitro-3-oxido-2,1,3-benzoxadiazol-3-ium
Canonical SMILESCN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-]
分子式C11H13N5O4
分子量279.25
溶解度DMF: 15 mg/mL,DMF:PBS (pH 7.2) (1:4): 0.2mg/mL,DMSO: 2 mg/mL,Ethanol: 1 mg/mL
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NSC 207895 is a small-molecule inhibitor of MDMX with GI50 value of 117nM [1].

NSC 207895 is a benzofuroxan derivative and is less toxic. NSC 207895 decreases the activity of MDMX promoter and subsequently decreases both the mRNA and protein levels of MDMX in MCF-7 cells. This inhibition of MDMX is accompanied with the activation of p53. NSC 207895 induces apoptosis in MCF-7 cells since it induces pro-apoptotic gene expression. It is found that the cleavage of PARP is significantly induced by NSC 207895 [2].

NSC 207895 is also found to be a DNA-damaging agent. It shows strong functional interactions with both DNA repair and replication fork complexes. NSC 207895 activates the DNA damage response (DDR) and leads a delay in cell cycle progression [3].

References:
[1] Hawes JJ, Nerva JD, Reilly KM. Novel dual-reporter preclinical screen for antiastrocytoma agents identifies cytostatic and cytotoxic compounds. J Biomol Screen. 2008 Sep;13(8):795-803.
[2] Wang H, Ma X, Ren S, Buolamwini JK, Yan C. A small-molecule inhibitor of MDMX activates p53 and induces apoptosis. Mol Cancer Ther. 2011 Jan;10(1):69-79.
[3] Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21;6:451.

 
 
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