Aminophylline

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Aminophylline

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	317-34-0
规格:	≥98%

包装与价格：

包装	价格(元)
1g	询价
5g	询价
10g	询价

理化性质和储存条件

Molecular Weight (MW)	420.43
Formula	C16H24N10O4
CAS No.	317-34-0
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 53 mg/mL (126.1 mM)
	Water: 84 mg/mL (199.8 mM)
	Ethanol: <1 mg/L
Chemical Name	1,3-Dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine
Synonyms	Cardophyllin; Aminophyllin; Aminophylline; Theophyllamine; Phyllocontin; Euphyllin; Truphylline; Minomal R 175 mg tab; Minomal R 350 mg tab; Minomal SR 600 mg tab Chemical Name: 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione compound with ethane-1,2-diamine (2:1) InChi Key: FQPFAHBPWDRTLU-UHFFFAOYSA-N InChi Code: InChI=1S/2C7H8N4O2.C2H8N2/c21-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h23H,1-2H3,(H,8,9);1-4H2 SMILES Code: CN1C2=C(NC=N2)C(N(C)C1=O)=O.CN3C4=C(NC=N4)C(N(C)C3=O)=O.NCCN

实验参考方法

In Vitro	In vitro activity: Aminophylline causes bronchodilation, diuresis, central nervous system and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenosine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis, and induces release of epinephrine from adrenal medulla cells. Kinase Assay: Aminophylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene[14] synthesis, and reduces inflammation and innate immunity and nonselective adenosine receptor antagonist.
References	Acad Emerg Med. 2003 Mar;10(3):192-7.

In Vitro

In vitro activity: Aminophylline causes bronchodilation, diuresis, central nervous system and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenosine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis, and induces release of epinephrine from adrenal medulla cells.

Kinase Assay: Aminophylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene[14] synthesis, and reduces inflammation and innate immunity and nonselective adenosine receptor antagonist.

References

Acad Emerg Med. 2003 Mar;10(3):192-7.