GABAA receptor modulator-2

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CAS NO:

2413850-54-9

GABAA receptor modulator-2 (Compound 20) 是一种选择性的、具有口服活性的α5-GABA_AR负向变构调节剂，K_i值为 4.1 nM。GABAA receptor modulator-2 具有高代谢稳定性和良好的中枢神经系统安全性。

生物活性	GABAA receptor modulator-2 (Compound 20) is selective, orally activeα5-GABA_ARnegative allosteric modulator (NAM) with aK_iof 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety^[1].
IC₅₀& Target	K_i: 4.1 nM (hα5)^[1]
体内研究 (In Vivo)	GABAA receptor modulator-2 (Compound 20) (0-10 mg/kg) produces a dose-dependent reversal of the PCP-induced cognitive deficit in the rat subPCP NOR test^[1].
分子量	459.49
Formula	C₂₂H₂₂FN₃O₅S
CAS 号	2413850-54-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.