(-)-Bicuculline methochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

53552-05-9

l-Bicuculline methochloride

(-)-Bicuculline methochloride (l-Bicuculline methochloride) 是一种有效的GABA_A受体拮抗剂。(-)-Bicuculline methochloride 在神经元中阻断 Ca²⁺激活的 K⁺通道介导的后超极化 (AHPs)。

生物活性

(-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potentGABA_Areceptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca²⁺-activated K⁺channels in various types of neurons^[1].

IC₅₀& Target

GABA_A^[1]

体内研究
(In Vivo)

(-)-Bicuculline methochloride (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin^[2].

Animal Model:	Rat L5-SNL model^[2]
Dosage:	0.6 nmol/rat
Administration:	Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.)
Result:	Attenuated the antiallodynic effect of Neurotropin.

分子量

417.84

Formula

C₂₁H₂₀ClNO₆

CAS 号

53552-05-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.