NBQX disodium

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NBQX disodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

479347-86-9

FG9202 disodium

NBQX disodium (FG9202 disodium) 是高度选择性，竞争型的AMPA受体拮抗剂。NBQX disodium 具有神经保护和抗惊厥活性。

生物活性

NBQX disodium (FG9202 disodium) is a highly selective and competitiveAMPA receptorantagonist. NBQX disodium has neuroprotective and anticonvulsant activity^[1].

IC₅₀& Target

AMPA receptor^[1]

体外研究
(In Vitro)

NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex^[1].

体内研究
(In Vivo)

NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ^[2].
NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion^[1].

Animal Model:	Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)^[2]
Dosage:	20 mg/kg
Administration:	IP; for 3 days
Result:	Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.

分子量

380.24

Formula

C₁₂H₆N₄Na₂O₆S

CAS 号

479347-86-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.