TC HSD 21 是一种有效的 17β-hydroxysteroid dehydrogenase type 3 (17⛚-HSD3) 抑制剂，IC50 为 14 nM。 TC HSD 21 对 17β-HSD 同工酶和核受体具有出色的选择性。
| Cas No. | 330203-01-5 |
| 化学名 | (Z)-5-(3-bromo-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one |
| Canonical SMILES | COC1=CC=C(N(C2=S)C(/C(S2)=C([H])/C3=CC(Br)=C(O)C=C3)=O)C=C1 |
| 分子式 | C17H12BrNO3S2 |
| 分子量 | 422.32 |
| 溶解度 | <42.23mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors[1]. References:
[1]. Harada K,et al. Identification of oxazolidinediones and thiazolidinediones as potent 17β-hydroxysteroid dehydrogenase type 3 inhibitors. Bioorg Med Chem Lett. 2012 Jan 1;22(1):504-7. |
