Velpatasvir (VEL, GS-5816) 是一种新型泛基因型丙型肝炎病毒 (HCV) 非结构蛋白 5A (NS5A) 抑制剂，具有针对基因型 1 (GT1) 至 GT6 HCV 复制子的活性。 Velpatasvir 也是一种 SARS-CoV 3CLpro 抑制剂，IC50 为 2.16 μM。
| Cas No. | 1377049-84-7 |
| 别名 | 维帕他韦; GS-5816 |
| Canonical SMILES | O=C(N([C@H]1C)[C@@H](CC1)C2=NC3=C(C(C=C(OCC4=CC(C5=CN=C([C@H](C[C@H](COC)C6)N6C([C@@H](C7=CC=CC=C7)NC(OC)=O)=O)N5)=CC=C84)C8=C9)=C9C=C3)N2)[C@H](C(C)C)NC(OC)=O |
| 分子式 | C49H54N8O8 |
| 分子量 | 883 |
| 溶解度 | DMSO : 146.66 mg/mL (166.09 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons.target: NS5A References:
[1]. Lawitz EJ et al. Clinical Resistance to Velpatasvir (GS-5816), a Novel Pan-Genotypic Inhibitor of the Hepatitis C Virus NS5A Protein. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5368-78. |
