LP44 (hydrochloride) 是一种选择性 5-HT7 激动剂，Ki 为 0.22 nM。
| Cas No. | 824958-12-5 |
| 化学名 | (R)-6-(4-(2-(methylthio)phenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide hydrochloride |
| Canonical SMILES | O=C(CCCCCN1CCN(C2=CC=CC=C2SC)CC1)N[C@@H]3CCCC4=CC=CC=C34.Cl |
| 分子式 | C27H37N3OS.HCl |
| 分子量 | 488.13 |
| 溶解度 | 10mg/mL in ethanol, or in DMSO, or in DMF |
| 储存条件 | Desiccate at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 |
LP44 is a full agonist of the serotonin 5-HT7 receptor (Ki = 0.22 nM) that displays 200- and greater than 1,000-fold selectivity over 5-HT1A (Ki = 52.7 nM) and 5-HT2A (Ki = 326 nM) receptors, respectively.1 It can induce relaxation of substance P-induced guinea pig ileum contraction with an EC50 value of 2.56 μM.[1] Reference:
[1]. Leopoldo, M., Berardi, F., Colabufo, N.A., et al. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents. J.Med.Chem 47, 6616-6624 (2004). |
