Fosinopril

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Fosinopril

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

98048-97-6

SQ28555 free acid

Fosinopril (SQ28555 free acid) 是血管紧张素转换酶 (ACE) 抑制剂的酯前产物，IC₅₀为 0.18 μM。Fosinopril 对ACE活性具有非竞争性抑制作用，其K_i值为 1.675 μM。

生物活性

Fosinopril (SQ28555 free acid) is the ester prodrug ofangiotensin-converting enzyme(ACE) inhibitor with anIC₅₀value of 0.18 μM. Fosinopril demonstrates a non-competitive inhibition effect onACEactivity with anK_ivalue of 1.675 μM^[1]^[2].

IC₅₀& Target

IC50: 0.18 μM^[1]; Ki: 1.675 μM^[2]

体外研究
(In Vitro)

Fosinopril (0-100μM; 30 min) partially inhibits the cosedimentation of liposomes and recombinant LPLA2^[1].
Fosinopril (250 nM) shows no inhibition of the soluble esterase activity of LPLA2^[1].
Fosinopril (0.372, 0.744, 1.116 μM) displays a non-competitive inhibition effect on ACE activity with an K_ivalue of 1.675 μM^[2].

体内研究
(In Vivo)

Fosinopril (4.67 mg/kg; p.o.; 4 weeks) downregulates the creatine kinase (CK) and lactate dehydrogenase (LDH) levels and againsts cardiac dysfunction and structural alteration in rat^[3].
Fosinopril (4.67 mg/kg; p.o.; 4 weeks) suppresses cleaved-caspase 3 expression and myocardial apoptosis in AMI rat model^[3].

Animal Model:	HF post-acute myocardial infarction (AMI) rat model (SPF-grade Sprague-Dawley (SD) rats, 265 ± 15 g)^[3]
Dosage:	4.67 mg/kg
Administration:	Oral gavage; 4 weeks
Result:	Inhibited cardiac dysfunction and structural alteration and suppressed apoptosis.

Clinical Trial

分子量

563.66

Formula

C₃₀H₄₆NO₇P

CAS 号

98048-97-6

中文名称

福辛普利

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.