Peimisine hydrochloride

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CAS NO:

900498-44-4

Ebeiensine hydrochloride

Peimisine (Ebeiensine) hydrochloride 是一种毒蕈碱 M 受体拮抗剂和血管紧张素转换酶 (ACE) 抑制剂。Peimisine hydrochloride 具有抗肿瘤、抗炎、抗高血压的活性。Peimisine hydrochloride 能诱导细胞凋亡，可用于咳嗽和哮喘研究。

生物活性

Peimisine (Ebeiensine) hydrochloride is amuscarinic M receptorantagonist andangiotensin converting enzyme(ACE) inhibitor. Peimisine hydrochloride shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induceapoptosisand be used in cough and asthma research^[1]^[2]^[3].

体外研究
(In Vitro)

Peimisine (17.43-92.07 μg/mL; 72 h) shows significant cytotoxic effects^[3].
Peimisine (15 μg/mL; 24, 48 and 72 h) induces G₀/G₁phase arrest and rising apoptosis rate^[3].

Apoptosis Analysis^[2]

Cell Line:	A2780 cells
Concentration:	15 μg/mL
Incubation Time:	24, 48 and 72 hours
Result:	Induced G₀/G₁phase arrest of A2780 cells in a time-dependent manner.

Cell Cytotoxicity Assay^[2]

Cell Line:	LLC, A2780, HepG2 and A549 cells
Concentration:	17.43-92.07 μg/mL
Incubation Time:	72 hours
Result:	Inhibited LLC, A2780, HepG2 and A549 cells with the IC₅₀values of 20.75 μg/mL, 17.43 μg/mL, 92.07 μg/mL, 36.11 μg/mL, respectively.

分子量

464.08

Formula

C₂₇H₄₂ClNO₃

CAS 号

900498-44-4

中文名称

贝母辛盐酸盐

结构分类

Alkaloids
Piperidine Alkaloids

来源

Plants
Liliaceae
Fritillaria ussuriensisMaxim.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.