Dorzolamide

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Dorzolamide

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CAS NO:

120279-96-1

多佐胺
L671152
MK507

Dorzolamide (L671152) 是有效的碳酸酐酶carbonic anhydrase II的抑制剂，其对红细胞 CA-II 和 CA-I 的IC₅₀值分别为 0.18 nM 和 600 nM。

生物活性

Dorzolamide (L671152) is a potentcarbonic anhydraseIIinhibitor, withIC₅₀values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity^[1].

体外研究
(In Vitro)

Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC₅₀of 2.4 μM (95% confidence interval: 0.5-10.85 μM)^[2].

体内研究
(In Vivo)

Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively)^[3].

Animal Model:	Female Swiss albino mice (EAC solid tumor)^[3].
Dosage:	3, 10, or 30 mg/kg/day (synergized mitomycin C).
Administration:	IP, daily for 3 weeks.
Result:	Upregulated TXNIP and p53 while downregulated bcl-2. Effective in retarding the growth of EAC in mice.

Clinical Trial

分子量

324.44

Formula

C₁₀H₁₆N₂O₄S₃

CAS 号

120279-96-1

中文名称

多佐胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.