Donepezil-d4 hydrochloride (E2020-d4) is the deuterium labeled Donepezil hydrochloride. Donepezil Hydrochloride (E2020) is a reversible, selectiveAChEinhibitor with anIC₅₀of 6.7 nM forAChEactivity. Donepezil shows high selectivity forAChEover BuChE^[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity^[2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

419.98

Solid

C₂₄H₂₆D₄ClNO₃

1219798-88-5

盐酸多奈哌齐 d4 (盐酸盐)

Room temperature in continental US; may vary elsewhere.