Ibiglustat succinate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1629063-80-4

Venglustat succinate
SAR402671 succinate
GZ402671 succinate

Ibiglustat (Venglustat) succinate 是一种具有口服活性的，可透过血脑屏障地葡糖神经酰胺合酶(GCS)抑制剂。Ibiglustat succinate 可用于研究戈谢病 3 型、与 GBA 突变相关的帕金森病、法布瑞氏症、GM2 神经节苷脂病和常染色体显性多囊肾病。

生物活性

Ibiglustat (Venglustat) succinate is an orally active, brain-penetrantglucosylceramide synthase (GCS)inhibitor. Ibiglustat succinate can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease^[1]^[2].

体外研究
(In Vitro)

Ibiglustat (SAR402671) succinate (1 μM, 15 days; Fabry disease (FD) cells) is close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat succinate can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes^[4].

Clinical Trial

分子量

507.57

性状

Solid

Formula

C₂₄H₃₀FN₃O₆S

CAS 号

1629063-80-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 250 mg/mL(492.54 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.9702 mL	9.8509 mL	19.7017 mL
5 mM	0.3940 mL	1.9702 mL	3.9403 mL
10 mM	0.1970 mL	0.9851 mL	1.9702 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。