Keap1-Nrf2-IN-8 (compound 12d) 是一种有效的Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction)抑制剂，IC50在 FP 和 TR-FRET 测定方法中分别为 64.5 nM 和 14.2 nM。Keap1-Nrf2-IN-8 显著增加 Nrf2 下游基因 GSTM3、HMOX2 和 NQO1 的 mRNA 水平。
| 生物活性 | Keap1-Nrf2-IN-8 (compound 12d) is a potentKeap1-Nrf2PPI (Keap1-Nrf2 protein–protein interaction)inhibitor withIC50s of 64.5 nM and 14.2 nM forFPand TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
