DHMEQ racemate

立即咨询

DHMEQ racemate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

287194-38-1

rel-DHMEQ

DHMEQ racemate 是一种NF-κB抑制剂。 DHMEQ racemate 抑制 NF-κB 的活性低于 (-)-DHMEQ。

生物活性

DHMEQ racemate is aNF-κBinhibitor. DHMEQ racemate is less active than (-)-DHMEQ.

IC₅₀& Target^[1]

NF-κB

体外研究
(In Vitro)

DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibits TNF-a-induced NF-kB activation. (-)-DHMEQ is more potent and less toxic than DHMEQ racemate^[1].

体内研究
(In Vivo)

The antiarthritic effects of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) are examined on type-II collagen-induced arthritis in DBA1/J mice. This animal model is widely used for evaluation of antirheumatic drugs because of its pathological similarities to human rheumatoid arthritis. The arthritis is elicited and scored. (-)-DHMEQ markedly inhibits type-II-collagen-induced arthritis in mice, whereas DHMEQ racemate tends to only slightly inhibit it^[1].

分子量

261.23

Formula

C₁₃H₁₁NO₅

CAS 号

287194-38-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vitro:

DMSO : ≥ 32 mg/mL(122.50 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.8280 mL	19.1402 mL	38.2804 mL
5 mM	0.7656 mL	3.8280 mL	7.6561 mL
10 mM	0.3828 mL	1.9140 mL	3.8280 mL