Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts ofTerminalia chebula,Terminalia bellerica, andPhyllanthus emblica^[1]. Triphala inhibitsNF-κBactivation. Triphala exertsantifungalaction^[2]. Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.

Triphala regulates adipogenesis through modulation of expression of adipogenic genes in 3T3-L1 cell line. Triphala significantly decreases the adipogenesis in 3T3-L1 cells by reducing lipid accumulation and inhibiting the expression of adipogenic genes. The 3T3-L1 cells treated with Triphala show ~1.43-, 1.67-, and 2.5-fold decreases in lipid content at 1, 10, and 100 μg/mL concentrations, respectively, compared to the cells treated with induction cocktail alone. Triphala regulates lipid accumulation by down regulating expression of adipogenic genes, resulting into prevention of adipogenesis^[1].
Triphala reduces expression of inflammatory mediators such as IL-17, COX-2, and RANKL through inhibition of NF-κB activation^[2]. Triphala exerts antifungal action againstAsperigillusspecies and has been reported to inhibit the fungus by up to 37.96% in vitro^[2].

Solid

857906-76-4

三果宝

• Others

• Plants
• Combretaceae
• Terminalia chebulaRetz.

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