Uric acid sodium (Monosodium urate) 是氧自由基(oxygen radical)的清除剂，是一种非常重要的抗氧化剂，有助于维持血压的稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS)，如单线态氧和过氧亚硝酸盐，抑制脂质过氧化。
| 生物活性 | Uric acid sodium (Monosodium urate), scavenger ofoxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can removereactive oxygen species(ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2]. |
| IC50& Target[1] | Human Endogenous Metabolite |
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体外研究
(In Vitro) | Uric acid (400 μM; 48 hours) sodium protects Caco-2 cells from indomethacin-induced lipid peroxidation[2].
Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) sodium significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) sodium is higher than that in cells treated with indomethacin alone. Uric acid sodium has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity[2].
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体内研究
(In Vivo) | Uric acid (250 mg/kg; p.o.) sodium ameliorates indomethacin-induced enteropathy[2].
Oral administration of uric acid sodium decreases ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy[2].
| Animal Model: | Eight-week-old male C57BL/6J mice[2] | | Dosage: | 250 mg/kg body weight | | Administration: | P.o. | | Result: | When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| 溶解性数据 | In Vitro: DMSO : 3.12 mg/mL(16.41 mM;ultrasonic and warming and adjust pH to 4 with HCl and heat to 60℃) 配制储备液 | 1 mM | 5.2607 mL | 26.3033 mL | 52.6067 mL | | 5 mM | 1.0521 mL | 5.2607 mL | 10.5213 mL | | 10 mM | 0.5261 mL | 2.6303 mL | 5.2607 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
